Polycyclic Aromatic Hydrocarbons: Chemistry and CarcinogenicityCUP Archive, 1991/11/07 - 396 ページ Polycyclic aromatic hydrocarbons, many of which have been identified as potent human carcinogens, occur widely in the environment as a result of incomplete combustion of fossil fuels and other organic matter. Major sources of emissions are wood and coal burning, automobiles, heat and power plants, and refuse burning. This volume reviews the chemistry of polycyclic aromatic hydrocarbons and their active metabolites, providing up-to-date information on their chemical and physical properties, methods of synthesis, environmental occurrence, and chemical reactions. It also surveys their biological properties, metabolism and metabolic activation, and current concepts concerning their mechanisms of carcinogenesis. The emphasis throughout is on recent findings and newer methods and techniques. This book provides a comprehensive overview of this currently active field of research, bringing together in a single volume a large amount of information previously scattered throughout the scientific literature. It may be read with profit by anyone with an interest in the chemistry and metabolism of polycyclic aromatic hydrocarbons, environmental chemistry and chemical carcinogenesis. |
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5-methylchrysene absolute configuration acetic acid adducts affords alkylation Amer anhydride anthracene anti anti-BPDE arene oxides Aromatic Compounds aromatic ring atom bay region diol benz[a]anthracene benzo[a]pyrene benzo[c]phenanthrene benzylic binding bond Buu-Hoi Cancer Res Carcinogenesis carcinogenic carcinogenic activity Chem chemical chrysene Clar conformation covalent cyclization dehydrogenation dibenz[a,h]anthracene Diels-Alder Diels-Alder reaction dihydrodiols DMBA enantiomers Fieser fluoranthene hydrogen hydroxyl IARC intermediate isomeric isomers Jerina Karcher ketone Lee & Harvey metabolism metabolites method methyl microsomal molecular molecules mouse skin mutagenic naphthalene nucleophiles Occurrence and carcinogenicity Oesch OH OH Orchin oxepin oxides oxidized metabolites PAHs Pataki perylene phenanthrene phenols Physical and spectral polyarenes polycyclic aromatic hydrocarbons polycyclic hydrocarbons polynuclear aromatic hydrocarbons protons pyrene quinones reaction reactivity reagent reduction region diol epoxide ring systems Spectral data spectral properties steric structure syn-BPDE Synthesis Synthetic routes Tetrahedron Lett trans-dihydrodiols triphenylene tumor tumor-initiating tumorigenic Yagi yield