The Synthesis of Tamoxifen and 4-hydroxytamoxifen Analogs for Estrogen Receptor-targeted ApplicationsUniversity of California, Davis, 2003 - 568 ページ |
目次
Abstract ii | 2 |
Synthesis of Lipidic Tamoxifen | 51 |
4HydroxytamoxifenLinked Chelates | 82 |
他の 21 セクションは表示されていません
多く使われている語句
13C NMR 2-hydroxy-2-methylpropanal acid addition alcohol alkylation analog aqueous aryl boronic ester breast cancer bromide BSTFA calc'd carbonyl CH2Cl2:MeOH chelate Chem chloride combined organic compounds coupling derivatization diastereomers diethylstilbestrol dried Na2SO4 DTPA epoxidation epoxidation reaction EPR spectra equiv ER-binding ER-rich estradiol estrogen receptor Et₂O ethyl side chain extracted Figure formation H NMR halogenated HOTam HOTam-DTPA HRMS hydroxycarbonyls hydroxytamoxifen hyperfine imaging agents interactions intermediate ionization ions at m/z isomer Katzenellenbogen keto-acids ketone ligand ligand binding lipidic tamoxifen m-CPBA m/z rel intens Magnetic Field mass spectra McCague methane mmol Mn(III Mn(IV mode spectra NMR 300 MHz NMR 75 MHz oxidation palladium-mediated perpendicular mode PFBHA-BSTFA derivative PFBOH phenol raloxifene reaction mixture reflux removed by rotary reported residue room temperature rotary evaporation salen sample Scheme side chain solution species stirred synthesis of tamoxifen tamoxifen tamoxifen synthesis tissue vinyl yellow oil yield