DNA Fingerprinting: State of the ScienceSergio D. J. Pena Springer, 1993 - 466 ページ DNA fingerprinting had a well-defined birthday. In the March 7, 1985 issue of Nature, Alec Jeffreys and coworkers described the first develop ment ofmu1tilocus probes capable of simultaneously revealing hypervari ability at many loci in the human genome and called the procedure DNA fingerprinting. It was a royal birth in the best British tradition. In a few months the emerging technique had permitted the denouement of hith erto insoluble immigration and paternity disputes and was already heralded as a major revolution in forensic sciences. In the next year (October, 1986) DNA fingerprinting made a dramatic entree in criminal investigations with the Enderby murder case, whose story eventually was turned into a best-selling book ("The Blooding" by Joseph Wambaugh). Today DNA typing systems are routinely used in public and commercial forensic laboratories in at least 25 different countries and have replaced conventional protein markers as the methods of choice for solving paternity disputes and criminal cases. Moreover, DNA fingerprinting has emerged as a new domain of intense scientific activity, with myriad applications in just about every imaginable territory of life sciences. The Second International Conference on DNA Fingerprinting, which was held in Belo Horizonte, Brazil in November of 1992, was a clear proof of this. |
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G Vergnaud D Gauguier J J Schott D Lepetit V Lauthier | 47 |
B Olaisen M Bekkemoen P HoffOlsen and P Gill | 63 |
P Vagnarelli E Giulotto P Fattorini E Mucciolo M Bensi | 71 |
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1993 Birkhäuser Verlag A. J. Jeffreys allele frequencies amplification analysis analyzed band sharing band-sharing Birkhäuser Verlag Basel/Switzerland Budowle Caucasian cells Chakraborty chromosome clones cruzi databases detected digestion distribution DNA fingerprinting DNA fragments DNA profiles DNA sequences DNA typing electrophoresis Epplen & A. J. Epplen JT estimates forensic fragile X syndrome GACA gene genomic DNA genotype groups heterozygosity Hum Genet human DNA human genome hybridization identified individuals intron Isérables isolated J. T. Epplen linkage locus male Mapuche markers mating methods microsatellites molecular multilocus DNA fingerprinting mutation mutation rate myotonic dystrophy Nucleic Acids Nucleic Acids Res obtained offspring oligonucleotide probes PCR products polymerase chain reaction polymorphic primer protein Reference population region repeat units S. D. J. Pena simple repeat Southern blot species strains tandem repeats telomere tion unrelated variability Vergnaud VNTR VNTR loci Yanomami