Evolutionary Biology of Aging
Oxford University Press, 1994/10/27 - 240 ページ
This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerful determining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the central thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.
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1 The Evolutionary Theory of Aging
2 Observation of Aging
3 Experimental Tests of the Evolutionary Theory of Aging
4 Genetic Mechanisms for the Evolution of Aging
5 Comparative Biology of Aging
6 An Evolutionary Perspective on Organismal Theories of Aging
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adult age-specific survival alleles antagonistic pleiotropy biology of aging cell cultures cellular chromosomal collagen comparative death decline deterioration discussed in Chapter disease Drosophila early reproduction effects elegans environmental error catastrophe evidence evolution of aging evolutionary biology evolutionary theory exhibit experimental experiments fecundity females fitness components function gene genetic correlations genetic variation genotype gerontology give rise Hayflick Hayflick limit hormones hypothesis inbreeding depression increase invertebrates iteroparous laboratory late-reproduced later ages life-history characters lipofuscin loci Luckinbill males Malthusian parameter mammals maximum longevities Maynard Smith mechanisms of aging Medawar melanogaster metabolic metazoa molecular mortality natural selection normal nutritional organismal organisms particular physiological mechanisms population genetics postponed aging prediction problem proliferation protein rate-of-living rates rodent Rose and Charlesworth semelparous senescence shown in Figure soma somatic mutation span species stocks Strehler studies suggests survival probability temperature tests theory of aging tion tissue vertebrates vitro cell Weismann
204 ページ - Ruley, HE (1983) Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.
vii ページ - In almost any other important biological field than that of senescence, it is possible to present the main theories historically, and to show a steady progression from a large number of speculative, to one or two highly probable, main hypotheses. In the case of senescence this cannot profitably be done. ... It is a striking feature of these theories (of senescence) that they show little or no historical development; they can much more readily be...