Epstein-Barr Virus: Latency and Transformation

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Erle S. Robertson
Horizon Scientific Press, 2010 - 200 ページ
EpsteinûBarr virus (EBV) is a human gamma herpes virus that is best known for being the causative agent of infectious mononucleosis in man. A fascinating feature of this virus is its ability to persist in the host and it is estimated that more than 95 of adults are carriers of the virus. Importantly, EBV can transform latently infected primary cells from healthy individuals into cancerous ones, thereby causing important human cancers such as B-cell neoplasms (e.g. Burkitt's lymphoma and Post-transplant lymphomas), certain forms of T-cell lymphoma, and some epithelial tumours (e.g. gastric carcinomas). Understanding viral latency, what triggers viral reactivation and the mechanism of transformation of normal host cells into malignant cells are critical for the development of strategies for the prevention and control of this intriguing virus and related cancers.

In this book, expert EBV virologists comprehensively review this important subject from a genetic, biochemical, immunological, and cell biological perspective. Topics include: latent infections, EBV leader protein, EBNA-1 in viral DNA replication and persistence, EBNA-2 in transcription activation of viral and cellular genes, the nuclear antigen family 3 in regulation of cellular processes, molecular profiles of EBV latently infected cells, latent membrane protein 1 oncoprotein, regulation of latency by LMP2A, role of noncoding RNAs in EBV-induced cell growth and transformation and the regulation of EBV latency by viral lytic proteins. This book is essential reading for all EBV virologists as well as clinical and basic scientists working on oncogenic viruses.
 

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目次

Latent EpsteinBarr Virus Infections
11
EpsteinBarr Virus Leader Protein
25
EBNA2 in Transcription Activation of Viral and Cellular Genes
61
Regulation of Cellular Processes by the EpsteinBarr Virus Nuclear
81
Molecular Profiles of EBV Latently Infected Cells
101
Biomolecular Separation and Analysis 2009
102
The EBV Latent Membrane Protein 1 Oncoprotein
117
Regulation of EBV Latency by LMP2A
135
The Role of Noncoding RNAs in EBVinduced Cell Growth and Transformation
155
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