Animal Cell Technology: Basic & Applied Aspects: Proceedings of the Fourth Annual Meeting of the Japanese Association for Animal Cell Technology, Fukuoka, Japan, 13–15 November 1991H. Murakami, Sanetaka Shirahata, H. Tachibana Springer Science & Business Media, 1992/07/31 - 584 ページ New data on animal cell technology are brought together in this volume, with emphasis given to the basic characterization of cell lines. The merits of different cell culture systems are examined and investigations into the factors influencing cell growth and productivity are presented. A special section deals with the biological properties of proteins produced by engineered animal cells. All those involved in the culture of animal cells will find this volume invaluable. |
目次
THE VALUE OF MODELS IN ANIMAL CELL BIOTECHNOLOGY | 1 |
THE MANZANAR PROJECT A UNIQUE WAY TO END WORLD HUNGER | 7 |
EXPERIENCE IN CELL LINE TESTING | 9 |
VIRUS REMOVAL AND INACTIVATION IN PROCESS VALIDATION | 15 |
STABILITY STUDIES AND APPLICATION TO A HIDE RANGE OF SPECIES | 31 |
ALTERATION OF CELL SURFACE GLYCOPROTEINS THROUGH DIFFERENTIATION FROM A HUMAN HISTIOCITIC LYMPHOMA CELL ... | 41 |
REMOVABILITY OF VIRUS PARTICLES AND PERMEABILITY OF PROTEIN FROM CELL CULTURE MEDIUM USING CUPRAMMONIUM ... | 49 |
PERFUSED IMMOBILIZED CONTINUOUS SUSPENSION AND BATCH SUSPENSION CULTURES | 57 |
CELL GROWTH APOPTOSIS AND NATURE OF MACROMOLECULES RECOVERED FROM THE CULTURE FLUID | 303 |
A NOVEL VERO CELL LINE FOR USE AS A MAMMALIAN HOSTVECTOR SYSTEM IN SERUMFREE CULTURE | 311 |
SERUM FREE CULTURE OF HUMANHUMAN HYBRIDOMA SECRETING MONOCLONAL ANTIBODIES AGAINST STOMACH CANCER | 321 |
SERUMFREE MEDIA FOR THE GROWTH AND MAINTENANCE OF THE DIFFERENTIATED STATE OF KERATINOCYTES HEPATOCYTES... | 327 |
NEONATAL RAT | 335 |
PRODUCTION OF HUMAN ANTITHROMBINIII IN A SERUMFREE CULTURE OF CHO CELLS | 345 |
ITS APPLICATION TO HYBRIDOMA CULTURE AND MONOCLONAL ANTIBODY PRODUCTION | 353 |
EDF ERYTHROID DIFFERENTIATION FACTOR ACTIVIN A PRODUCTION IN RECOMBINANT CHO CELLS | 361 |
DYNAMICS OF AGGREGATE CULTURE OF MAMMALIAN CELLS | 65 |
EFFECT OF PROTEIN ADSORPTION ON CELL ATTACHMENT ON SOLID SURFACES | 71 |
CHARACTERIZATION OF CELL GROWTH AND IMPROVEMENT OF ATTACHMENT KINETICS ON MACROPOROUS MICROCARRIERS | 77 |
APPLICATION OF THREE DIMENSIONAL CULTURE OF ADULT RAT HEPATOCYTES IN PUF PORES FOR ARTIFICIAL LIVER SUPPORT S... | 81 |
NOVEL VALIDATION METHOD OF VIRUSREMOVABILITY FOR BIOLOGICAL CELL CULTURE PRODUCTS USING POLYMERIC MEMBR... | 87 |
SELECTIVE FORMATION AND IMMOBILIZATION BY REATTACHMENT OF FLOATING SPHEROIDS OF RAT HEPATOCYTES | 103 |
ENGINEERING OF ULTRAFILTRATION HOLLOW FIBER BIOREACTORS FOR MAMMALIAN CELL PROTEIN PRODUCTION | 109 |
PRODUCTION OF hEPO BY RECOMBINANT C127 CELLS USING HOLLOW FIBER CULTURE SYSTEM | 115 |
OSCILLATORY BEHAVIOR IN CONTINUOUS AGGREGATE CULTURES OF MAMMALIAN CELLS | 121 |
DETECTION OF MAMMALIAN CELL ATTACHMENT AND LYSIS ON A METAL SURFACE USING A PIEZOELECTRIC SENSOR | 129 |
STRATEGIES FOR ECONOMIC GMP PRODUCTION OF MAMMALIAN CELL EXPRESSED PROTEINS | 135 |
USE OF MEDIUM CONCENTRATES TO IMPROVE BIOREACTOR PRODUCTIVITY | 143 |
SEPARATION OF ANIMAL CELLS IN COTINUOUS CELLCULTURE SYSTEMS | 149 |
AN AUTOMATED SYSTEM FOR HOLLOW FIBER CELL CULTURE | 155 |
AUTOMATIC SELECTION SYSTEM OF MONOCLONAL ANTIBODY PRODUCING CELLS | 165 |
CONTINUOUS MONOCLONAL ANTIBODY PRODUCTION BY A COMPOSITE GEL PERFUSION BIOREACTOR IN A PROTEINFREE MEDIUM | 173 |
HIGH DENSITY CULTIVATION OF HYBRIDOMA CELLS BY USING PERMEABLE CAPILLARIES | 179 |
RECOGNITION AND COUNTING METHOD OF MAMMALIAN CELLS ON MICROCARRIER USING IMAGE PROCESSING AND NEURAL NE... | 185 |
MITOCHONDRIAL GENOME TRANSCRIPTION IN CULTURED ANIMAL CELLS | 193 |
LARGESCALE MAMMALIAN CELL CULTURES BY APPLICATION OF MACROPOROUS CELLULOSE CARRIERS | 201 |
HIGH DENSITY PERFUSION CULTURE OF ANIMAL CELLS USING A NOVEL CONTINUOUS FLOW CENTRIFUGE | 209 |
MEMBRANE DIALYSIS BIOREACTOR WITH INTEFRATED RADIALFLOW FIXED BED A NEW CONCEPT FOR CONTINUOUS CULTIVAT... | 217 |
EFFECT OF GLUTAMINE SUPPLEMENTATION ON THE GROWTH OF HYBRIDOMA CELLS CULTIVATED IN A REACTOR COUPLED WIT... | 225 |
VIRUS CONTAINMENT CONTINUOUS CULTURE OF ANIMAL CELLS | 233 |
A NOVEL BIOREACTOR PROCESS FOR ANCHORAGEINDEPENDENT ANIMAL CELLS IMMOBILIZED WITHIN POROUS BIOMASS SUPPO... | 239 |
EFFECTS OF ENVIRONMENTAL PARAMETERS ON CHO CELL GROWTH IN BATCH AND CHEMOSTAT CULTURES AND ON HUMAN IF... | 245 |
DESIGN AND CHARACTERIZATION OF ELECTRICALLY CONTROLLED BIOREACTOR | 251 |
MODULATION OF THE PROLIFERATION OF CULTURED HEP ATOM A CELLS BY UREA CYCLERELATED AMINO ACIDS | 257 |
THE EFFECTS OF GLUTAMINE CONCENTRATION ON GROWTH AND MONOCLONAL ANTIBODY PRODUCTION IN FEDBATCH OPERA... | 265 |
STIMULATION OF ANIMAL CELL METABOLISM BY SHEAR STRESS | 271 |
EFFECTS OF CONDITIONED MEDIUM ON THE GROWTH KINETICS AND THE MONOCLONAL ANTIBODY PRODUCTIVITY OF HYBRID... | 279 |
FACTORS INFLUENCING EXPRESSION AND POSTTRANSLATIONAL MODIFICATION OF RECOMBINANT PROTEIN C | 287 |
A SIMPLE AUTOMATIC CONTROL SYSTEM OF PH AND DO | 295 |
A NOVEL SERUM FREE MEDIUM FOR MOUSE HYBRIDOMAS AND HUMAN LYMPHOBLASTOID CELL LINES | 369 |
A SIMPLE STRUCTURED MODEL PREDICTED POSITIVELY NEGATIVELY OR NONGROWTH ASSOCIATED ANTIBODY PRODUCTION R... | 375 |
CHANGE IN MONOCLONAL ANTIBODY PRODUCTIVITY IN IMMOBILIZED HYBRIDOMA CELLS AT LOW DISSOLVED OXYGEN CONC... | 383 |
IMPROVED MONOCLONAL ANTIBODY PRODUCTION OF A HYBRIDOMA BY VARYING THE OXYGEN TENSION DURING A SUSPENSIO... | 391 |
ENHANCEMENT OF PRODUCTIVITY BY YIELD IMPROVEMENTS USING SIMULATION TECHNIQUES | 397 |
STUDIES ON THE PRODUCTION OF RECOMBINANT HUMAN NFIL6 IN MOUSE L CELL | 405 |
ENHANCING EFFECT OF INTERLEUKIN6 ON ANTIBODY PRODUCTIVITY OF A HYBRIDOMA CELL LINE | 413 |
IMPROVED PRODUCTION OF RECOMBINANT PROTEINS BY THE BACULOVIRUS EXPRESSION SYSTEM | 419 |
PRODUCTION AND PRODUCT INTEGRITY OF RECOMBIN ANT HIV1 gagPARTICLES p55 WITH THE BACULOVIRUS EXPRESSION SYST... | 425 |
ENHANCEMENT OF BIOLOGICAL PRODUCTIVITY IN SERUMFREE CULTURE | 431 |
ENHANCEMENT OF IGM PRODUCTION OF HB4C5 CELLS BY CHITOSAN | 439 |
REPRESSION OF OVALBUMIN GENE EXPRESSION IN THE CHICKEN OVIDUCT CELL | 445 |
CONSTITUTIVE LONGTERM PRODUCTION OF RECOMBINANT HUMAN INTERFERONGAMMA BY TRANSFORMED MOUSE C127 CELL... | 453 |
POSSIBLE INVOLVEMENT OF PROTEIN TYROSINE SULFATION IN THE POLARIZED PROTEIN TARGETING IN FILTERGROWN MADIN... | 463 |
PROTEIN TYROSINE SULFATION IN ANIMAL CELLS AND ITS SIMULATION IN VITRO IN THE DOWNSTREAM PROCESSING OF PROTE... | 473 |
EXPRESSION OF CARP 𝛂GLOBIN GENE IN TILAPIA OVARY CELLS | 481 |
IMMUNOSUPPRESSIVE FUNCTIONS OF CELLS FROM INTESTINAL TISSUES | 491 |
BIOLOGICAL FUNCTIONS OF CARBOHYDRATES IN ERYTHROPOIETIN | 499 |
CLONING AND EXPRESSION OF FLATFISH INTERLEUKIN 2 GENE | 509 |
SERUMFREE MOUSE EMBRYO SFME CELLS AND TRANSFORMING GROWTH FACTOR TGF𝛃1 | 514 |
ANTITETANUS HUMAN MONOCLONAL ANTIBODIESCOMPARATIVE STUDIES ON THEIR PROTECTIVE ACTIVITY WITH POLYCLONA... | 519 |
PRODUCTION OF CHICKEN MONOCLONAL ANTIBODY | 525 |
GENERATION AND CHARACTERIZATION OF MURINE ANTIHUMAN TRANSFORMING GROWTH FACTOR𝛃1 MONOCLONAL ANTIBOD... | 533 |
EXAMINATION OF LUNG CANCER USING A HUMAN MONOCLONAL ANTIBODY HB4C5CLONE 3 | 539 |
ALTERATION OF REACTIVITY OF HUMAN MONOCLONAL ANTIBODIES PRODUCED BY CONCANAVALIN ARESISTANT HYBRIDOMAS | 545 |
DEVELOPMENT OF MOUSE FIBROBLAST DERMAL EQUIVALENT USING TISSUE CULTURE TECHNIQUE | 551 |
EFFECTS OF SOME FOOD ADDITIVES AND MYCOTOXINS ON THE GROWTH OF HUH6KK CELLS | 557 |
| 563 | |
THE PROTECTIVE ROLE OF POLYPHENOLS IN CYTOTOXICITY OF HYDROGEN PEROXIDE | 569 |
Author Index | 575 |
Subject Index | 579 |
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