Toxicological Profile for Creosote (coal Tar and Wood), Coal Tar and Coal Tar Pitch: Draft

1-hydroxypyrene absorption acute ANALYTICAL METHODS anthracene ATSDR beechwood creosote benzo(a)pyrene biological biomarkers body weight carcinogenic chemical chronic coal tar creosote coal tar pitch coal tar products coal-tar components of coal compounds concentrations contaminated creosote and coal creosote bush creosote bush resin creosote components creosote exposure creosote mixture creosote oil creosote-treated cresols detected DMBA dose excreted exposed exposure to coal exposure to creosote following dermal exposure fractions genotoxic groundwater hazardous waste hazardous waste sites HEALTH EFFECTS HPLC HUMAN EXPOSURE humans or animals increased industrial ingestion inhalation exposure irritation isomer Jongeneelen limited LOAEL located regarding Louis Park lung metabolic metabolites mg/kg mg/kg/day mg/m³ mice Miyazato mouse mutagenic NIOSH NOAEL observed oral exposure PAH components PAHs pentachlorophenol Pfitzer phenolic pitch volatiles polycyclic aromatic hydrocarbons rats renal reported respiratory risk routes significant studies were located substance tissues TOMA toxic effects Toxicological Profile wood creosote wood preservative workers