Diabetes Mellitus: A Fundamental and Clinical TextDerek LeRoith, Simeon I. Taylor, Jerrold M. Olefsky Lippincott Williams & Wilkins, 2000 - 1067 ページ This revised and updated text on diabetes mellitus encompasses recent advances in molecular and cellular findings, and provides new therapeutic modalities for the disease. Adhering to the successful format of the first edition, the book is divided into ten distinct sections, each containing individual chapters that progress from basic mechanisms to physiology to therapeutic. It covers the complications of diabetes at both the basic and clinical levels. |
目次
Insulin Gene Regulation | 11 |
Pregnancy | 19 |
Electrophysiology of the Pancreatic BCell 47 Newsholme | 47 |
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Acad Sci USA adipocytes adipose tissue amino acid amyloid B-cell binding Biochem Biol Chem Ca2+ Cell Biol cellular Clin Invest cose cytosolic decrease diabetes mellitus domain effect of insulin Endocrinology enzyme fatty acid function G proteins gene expression gene transcription glucagon glucokinase glucose concentration glucose transport glucose uptake glycogen synthase hepatic hormone human hyperglycemia increased inhibition inhibitors insulin action insulin gene insulin receptor insulin release insulin resistance insulin secretion insulin signaling insulin-stimulated interaction intracellular isoforms KATP channels levels liver mechanism mediated metabolism mice molecular mRNA mutations Natl Acad Sci normal obesity overexpression pancreatic pancreatic B-cells pancreatic islets pathway patients PDK1 peptide phosphatase phosphorylation Physiol PI3K plasma membrane Proc Natl Acad proinsulin protein kinase PTPase rat adipocytes regulation role secretory sequence skeletal muscle stimulation studies substrate subunit sulfonylurea synthesis tein tion transgenic translocation type 2 DM tyrosine vesicle vitro vivo